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Fluid platelet-rich fibrin stimulates greater dermal skin fibroblast cell migration, proliferation, and collagen synthesis when compared to platelet-rich plasma
Cosmetic (1)
Feb 22, 2022

Xuzhu Wang DDS, PhD*- Yang Yand DDS,MSc* - Yufeng Zhang DDS, Phd* - Richard J. Miron DDS, PhD**
* The State Key Laboratoy Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan university, Wuhan,China - Department of ORal Implantology, School and Hospital of Stomatology, Wuhan University, Wuhan, China
** Department of Periodontology, University of Bern, Bern, Switzerland

Background: Regenerative therapies in the field of facial aesthetics have become growing field of interest with many recent advancements made over the past decade to meet the growing worldwide demand. While first versions of the platelet-derived concentrates were formulated with anticoagulants (PRP), recent modifications to centrifugation speeds and times have permitted the development of a liquid platelet-rich fibrin (fluid-prf) withou use of anticoagulants.


Objective: To compare this entirely natural platelet concentrate (fluid-PRF) to formally utilized PRF on skin cell behavior and regeneration.


Method: Dermal skin fibroblast was cultivated with either fluid-PRF or PRP and investigated for their ability to promote/influence cell variability, migration, spreading, proliferation, and mRNA levels of known mediators of dermal biology including PRDGF, TGF-bate, and fibronectin.


Results: All platelet concentrates were nontoxic to cells demonstrating high cell survival. Skin fibroblast migrated over 350% more un fluid-PRF when compared to control and PRF (200% increase). Fluid-PRF also significantly induced greater cell proliferation at 5 days. While both PRF and fluid-PRF induced signficantly elevated cell mRNA levels were all significantly highest in the fluid-PRF group. Lastly, fluid-PRF demonstrated a significantly greater ability to induce collagen matrix synthesis when compared to PRP.


Conclusion: The findings from teh present study demonstrate greater regenerative potential of fluid-PRF on human skin fibroblasts. Future clinical use of fluid-PRF in the fiels of facial aesthetics is necessary to further evaluate the potentiel advantages of anticoagulant removal from platelet concentrates.

Calculation for human identification:13-2 =

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