Joseph Choukroun (1) - Georges Khoury, DDS2 (2)  - Fouad Khoury, MD, PhD3 (3) - Philippe Russe, DDS4 (4) - Tiziano Testori, MD5 (5) - Yataro Komiyama, DDS, PhD6 (6)- Gilberto Sammartino, MD, PhD (7)- Patrick Palacci, DDS (8) - Mustafa Tunali, DDS, PhD (9) - Elisa Choukroun (10)

1- Pain clinic , Nice, France 2- University PAril IIV, Paris, France 3- Munster University, Olsberg, Germany 4- Private practice, Relms, France 5- Galeazzi Institute, universita di Milano, Milan, Italy 6- Branewark Osseointegraion Center, Tokyo, Japan 7- University Frederico 2, Napoli, Italy 8- Branewrk Osseointegration Center, Marseille, France 9- Haidarpasa Hospital, Istanbul, Turkey 10- University of Nice, France

Following a failure of a bone graft or an implant placement, the hypothesis of a biological abnormality is rarely considered as a possible cause. A systematic search of peer-reviewed literature for dyslipidemia or vitamin D deficiency may explain this lack of consideration. Excess low-density lipoprotein cholesterol (dyslipidemia) is responsible for a slower bone metabolism or lower dental implant osseointegration. In addition, vitamin D is a key factor for linking innate and adaptive immunity. Both of these factors are compromised under the conditions of vitamin D deficiency. Therefore, vitamin D deficiency slows implant osseointegration and increases the risk of graft infection. Vitamin D is also involved in immune function and therefore allergic reactions.