The concept of PRF is based on the centrifugation of whole blood without anticoagulants. At the end of the centrifugation, a fibrin clot is obtained containing platelets and a majority of white cells. This fibrin clot (Platelet Rich Fibrin or PRF) will progressively and constantly release growth factors into the medium (VEGF, PDGF, TGF, BETA, Thrombospondin).

The expected objective of these growth factors is to accelerate mucosal and bone healing.