PRF is obtained by centrifuging whole blood without any additives or anticoagulants. Platelet-rich fibrin, or PRF, is a unique platelet concentrate characterized by: the presence of cells (platelets, leukocytes and progenitor cells) and growth factors (PDGF, TGF, ICF, VEGF) that are essential for tissue repair and regeneration. The end result is a healing matrix with unique mechanical properties.

The benefit of PRF is not limited to muscle injuries, and recent studies have revealed its ability to promote bone healing and regeneration when applied with several grafting materials. I-PRF+ (liquid PRF) offers the hope of aiding both bone and muscle regeneration following severe trauma-induced injuries.