Jerome Surmenian*- Joseph Choukroun **
* Pratique privée, Nice, France, [email protected]
** Centre Anti-Douleur, Nice, France

In the last few decades different concepts have evolved for the best possible tissue regeneration in wounds, surgery and skin (Choukroun 2017, Dohle 2018). The use of PRP and its growth factors is attracting much attention amongst aestheticians, dermatologists and surgeons (Takura, 1996, Yildiz, 2016, Wang, 2016). Platelets contain high quantities of growth factors capable of stimulating cell proliferation (mitogenesis), matrix remodelling (Dohan, 2009) and vascular growth (angiogenesis) (Robert, 2001). See Table 1.
PRP is a relatively new biotechnology which is part of tissue engineering and cellular therapy (Robert, 2001). PRP originated 40 years ago where blood derived products were used to seal wounds and stimulate healing (Dohan, 2009). Some studies found that the drawback from PRP is that the additional use of anticoagulants inhibit wound healing (Wang, 2016). Furthermore, the optimal combination of each cellular component in PRP remains unknown due to the variety of commercially available PRP generating systems, which makes it difficult to know which PRP preparation is best for which clinical indication (Boswell, 2014).
Now a second-generation protocol emerged known as PRF (platelet rich fibrin) or Choukroun’s i-PRF. It differs from PRP in the sense that there is no anticoagulants or additives and are centrifuged at lower speed (Dohan, 2006). PRF has a mixture of platelets, white blood cells, bone morphogenic protein (BMP), stem cells and growth factors (Holistic, 2018).